If your use of RTXI leads to publication, please cite RTXI in your paper. We get our funding from the NIH, and citations will help when our grant renewal comes around. Cite:

Patel, Y.A., George, A., Dorval, A.D., White, J.A., Christini, D.J. and Butera, R.J., 2017. Hard real-time closed-loop electrophysiology with the Real-Time eXperiment Interface (RTXI). PLOS Computational Biology, 13(5), e1005430.

Below is our list of papers that cite RTXI. We're always on the lookout for new research, but we'd love to hear from you if you've got something in the works.



Kilohertz frequency nerve block enhances anti-inflammatory effects of vagus nerve stimulation

Illuminating Myocyte-Fibroblast Homotypic and Heterotypic Gap Junction Dynamics Using Dynamic Clamp

Cell-Specific Cardiac Electrophysiology Models

Membrane potential-dependent integration of synaptic inputs in entorhinal stellate neurons

Dynamic Clamp in Cardiac and Neuronal Systems Using RTXI

Voltage and Calcium Dynamics Both Underlie Cellular Alternans in Cardiac Myocytes

Predicting the Responses of Repetitively Firing Neurons to Current Noise

Tonic current through GABAA receptors and hyperpolarization-activated cyclic nucleotide-gated channels modulate resonance properties of rat subicular pyramidal neurons

EEG Feedback-Controlled Transcranial Alternating Current Stimulation

Parameterized Phase Response Curves for Characterizing Neuronal Behaviors under Transient Conditions

Optical Dissection of Odor Information Processing In Vivo Using GCaMPs Expressed in Specified Cell Types of the Olfactory Bulb

The Mechanism of Abrupt Transition between Theta and Hyper-Excitable Spiking Activity in Medial Entorhinal Cortex Layer II Stellate Cells

Spike Phase Locking in CA1 Pyramidal Neurons Depends on Background Conductance and Firing Rate

Statistics of Neuronal Identification with Open- and Closed-loop Measures of Intrinsic Excitability

Membrane Properties and the Balance between Excitation and Inhibition Control Gamma-Frequency Oscillations Arising from Feedback Inhibition

Short Conduction Delays Cause Inhibition Rather than Excitation to Favor Synchrony in Hybrid Neuronal Networks of the Entorhinal Cortex

Shaping a New Ca2+ Conductance to Suppress Early Afterdepolarizations in Cardiac Myocytes

Responses of a Bursting Pacemaker to Excitation Reveal Spatial Segregation between Bursting and Spiking Mechanisms

High Frequency, Short Latency Disinhibition Bursting of Midbrain Dopaminergic Neurons

Mixed Mode Oscillations in Mouse Spinal Motoneurons Arise from a Low Excitability State

Firing Rate Control of a Neuron Using a Linear Proportional-integral Controller

Modulation of Firing Rate by Background Synaptic Noise Statistics in Rat Visual Cortical Neurons

Rate Maintenance and Resonance in the Entorhinal Cortex

Compensation for Variable Intrinsic Neuronal Excitability by Circuit-synaptic Interactions

A Dynamic Role for GABA Receptors on the Firing Pattern of Midbrain Dopaminergic Neurons

Dynamic Clamp: Alteration of Response Properties and Creation of Virtual Realities in Neurophysiology

Cell Type-Specific Control of Neuronal Responsiveness by Gamma-Band Oscillatory Inhibition

Dynamical Mechanism for Subcellular Alternans in Cardiac Myocytes

Functional Phase Response Curves: a Method for Understanding Synchronization of Adapting Neurons

Reliable Neuromodulation from Circuits with Variable Underlying Structure

Predictions of Phase-Locking in Excitatory Hybrid Networks: Excitation Does Not Promote Phase-Locking in Pattern-Generating Networks as Reliably as Inhibition

Measuring Multiple Spike Train Synchrony

Causes of Transient Instabilities in the Dynamic Clamp

Reduction of Spike Afterdepolarization by Increased Leak Conductance Alters Interspike Interval Variability

Control of Neuronal Persistent Activity by Voltage-Dependent Dendritic Properties

Effects of Imperfect Dynamic Clamp: Computational and Experimental Results

Artificial Synaptic Conductances Reduce Subthreshold Oscillations and Periodic Firing in Stellate Cells of the Entorhinal Cortex

Resonant or Not, Two Amplification Modes of Proprioceptive Inputs by Persistent Inward Currents in Spinal Motoneurons

Optical Mapping System with Real-time Control Capability

State Changes Rapidly Modulate Cortical Neuronal Responsiveness

Temporal Coding by Cochlear Nucleus Bushy Cells in DBA/2J Mice with Early Onset Hearing Loss

Low-dimensional Maps Encoding Dynamics in Entorhinal Cortex and Hippocampus

Dynamic clamp: a powerful tool in cardiac electrophysiology

Serotonergic Enhancement of a 4-AP-sensitive Current Mediates the Synaptic Depression Phase of Spike Timing-dependent Neuromodulation

Bistable Network Behavior of Layer I Interneurons in Auditory Cortex

Synchronization in Hybrid Neuronal Networks of the Hippocampal Formation